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Filtered Search Results
Medchemexpress LLC Monomethyl auristatin E intermediate-3 | 265.30 | 250 MG
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Monomethyl auristatin E intermediate-3 is a reagent used in the synthesis of Monomethyl auristatin E (MMAE). MMAE acts as a microtubule/tubulin inhibitor, demonstrating anticancer activity and is commonly employed as the cytotoxic component in antibody-drug conjugates (ADCs).
- Intermediate reagent for Monomethyl auristatin E synthesis.
- Precursor to a microtubule/tubulin inhibitor.
- Used in antibody-drug conjugates (ADCs) as a cytotoxic component.
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eMolecules Pharmablock N-(4-acetamidophenyl)-N-fluorosulfonyl-sulfamoyl fluoride 250mg 840365239 PBUC450 0 000 2172794-56-6 314 280 C8H8F2N2O5S2
Pharmablock N-(4-acetamidophenyl)-N-fluorosulfonyl-sulfamoyl fluoride 250mg 840365239 PBUC450 0 000 2172794-56-6 314 280 C8H8F2N2O5S2
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Apexbio Technology LLC Puromycin aminonucleoside(Synonyms: Puromycin Aminonucleoside, Puromycin Nucleoside, 3'-Amino-3'-deoxyadenosine, PAN, NSC 3056, Puromycin Aminonucleosid, Adenosine, 3'-amino-3'-deoxy-), 250mg, CAS: 58-60-6.
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Puromycin aminonucleoside (CAS 58-60-6) is the aminonucleoside moiety derived from the antibiotic puromycin It induces nephrotic injury in experimental animal models leading to significant proteinuria and structural alterations in renal glomeruli In vitro treatment with puromycin aminonucleoside alters podocyte morphology characterized by reductions in cellular microvilli and disruption of foot-process structures In vivo administration in rats induces glomerular lesions resembling focal segmental glomerulosclerosis (FSGS) and lipid accumulation in mesangial cells This compound serves primarily as an investigative tool in elucidating mechanisms underlying nephrotic syndrome
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Medchemexpress LLC mPEG-CM MW 2000 250mg
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mPEG-CM (MW 2000) (mPEG-COOH (MW 2000)) has a reactive carboxyl group (-COOH) attached to the terminal site of the structure which can form a stable amide bond with the amino group or an ester bond with the hydroxyl group mPEG-CM (MW 2000) can be used for drug delivery[1]
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![Medchemexpress LLC 5,7-dichloro-[1,3]thiazolo[5,4-d]pyrimidine | 13479-88-4 | MFCD09702027 | ≥98.0% | 206.05 g/mol | C5HCl2N3S | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000302375.png-250.jpg)
Medchemexpress LLC 5,7-dichloro-[1,3]thiazolo[5,4-d]pyrimidine | 13479-88-4 | MFCD09702027 | ≥98.0% | 206.05 g/mol | C5HCl2N3S | 250 MG
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5,7-Dichlorothiazolo[5,4-d]pyrimidine (CAS 13479-88-4) is a chlorinated heterocyclic building block used as an intermediate in small-molecule and medicinal chemistry synthesis. It is supplied in research-scale quantities and is offered by chemical suppliers in defined purity grades for use in route scouting and heterocycle construction.
- Used as a synthetic building block for heterocycle construction and medicinal chemistry.
- Molecular formula C5HCl2N3S and molecular weight 206.05 g/mol.
- CAS number 13479-88-4 for unambiguous identification.
- Offered in small pack sizes suitable for research (50 mg-500 mg).
- Available in high-purity grades (reported ≥98% by some suppliers).
- Supplied with standard documentation such as COA and SDS for quality verification.
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Medchemexpress LLC GANT 61 | 500579-04-4 | 99.80% | 429.60 | 25 MG
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GANT 61 is a potent inhibitor of Gli1 and Gli2, effectively targeting the Hedgehog/GLI signaling pathway. This compound has demonstrated significant biological activity both in vitro and in vivo, impacting cell proliferation, viability, and tumor growth across various cancer models.
- Inhibits Gli1 and Gli2 activity
- Targets the Hedgehog/GLI pathway
- Reduces clonogenic survival in human colon carcinoma cells
- Induces apoptosis and inhibits cell viability in pancreatic cancer stem cells
- Inhibits motility, invasion, and migration of cancer stem cells
- Decreases tumor growth in xenograft models
- Enhances the effects of chemotherapeutic drugs for neuroblastoma
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Medchemexpress LLC Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin | 55216-11-0 | MFCD00010728 | >=98.0% | 1429.54 | C63H112O35 | 250 MG
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Heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin is a fully methylated β-cyclodextrin derivative used as a biochemical reagent for forming host-guest inclusion complexes, improving aqueous solubility of hydrophobic molecules, and acting as a chiral selector in separation methods. It is applied in formulation research, chiral separations, and physicochemical studies of molecular interactions.
- Fully methylated derivative that promotes strong host-guest interactions.
- Improves solubility and stability of hydrophobic compounds in water.
- Acts as a chiral selector for chromatographic and electrophoretic separations.
- Applicable to formulation and inclusion-complex studies.
- Provided in laboratory-scale quantities for research use.
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eMolecules Ethyl 2-(trifluoromethyl)-4-methyl-5-pyrimidine carboxylate | 306960-67-8 | 1G | Purity: 97%
Matrix Scientific | Ethyl 2-(trifluoromethyl)-4-methyl-5-pyrimidine carboxylate | 1G | 306960-67-8 | MFCD07367386
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eMolecules Building Block Tool
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Medchemexpress LLC Vafidemstat | 1357362-02-7 | 98.0% | 336.39 | 250 MG
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Vafidemstat (ORY-2001) is an oral, brain penetrant, dual lysine-specific histone demethylase (LSD1)/MAO-B inhibitor. It is a novel epigenetic agent developed for the treatment of neurodegenerative diseases. It modulates LSD1, which participates in transcription regulation complexes, to adjust transcriptional imbalances in neurodegenerative diseases and to address neuroinflammation and cognitive deficits. Vafidemstat (ORY-2001) can also be used in the treatment of Alzheimer's disease.
- Oral, brain penetrant.
- Dual lysine-specific histone demethylase (LSD1)/MAO-B inhibitor.
- Novel epigenetic agent for the treatment of neurodegenerative diseases.
- Modulates LSD1 to tweak transcriptional imbalances in neurodegenerative disease.
- Redresses neuroinflammation and cognitive deficit.
- Can be used in the treatment of Alzheimer's disease.
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Cayman Chemical W3 Arachidonic Acid ethyl est
ω-3 Arachidonic acid is a rare PUFA found in trace amounts in dietary sources. ω-3 Fatty acids are known to be essential for infant growth and development and they protect against heart disease, thrombosis, hypertension, as well as inflammatory and autoimmune disorders.{5525} In human platelet membranes, ω-3 arachidonic acid inhibits arachidonoyl-CoA synthetase with a Ki of 14 µM. It also inhibits arachidonoyl-CoA synthetase in calf brain extracts with an IC50 value of about 5 µM.{2166} ω-3 Arachidonic acid ethyl ester is a more lipophilic form of the free acid.
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Medchemexpress LLC Pyrimidine | 289-95-2 | MFCD00006059 | 100.0% | 80.09 | C4H4N2 | 25g
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Pyrimidine is a nitrogen-containing heterocyclic compound and endogenous metabolite Pyrimidine derivatives can be used in pancreatic cancer triple-negative breast cancer colon carcinoma and neuron research[1][2][3]
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Medchemexpress LLC Benzoic acid, 4-hydroxy-3-methoxy-, ethyl ester | 617-05-0 | 99.87% | 25 G
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Ethyl Vanillate is a fungicidal agent that inhibits 17β-HSD2 with an IC50 of 1.3 μM. It is for research use only.
- Fungicidal agent
- Inhibits 17β-HSD2
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Medchemexpress LLC 4-Hydroxyantipyrine | 1672-63-5 | 99.9% | 250 MG
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4-Hydroxyantipyrine is the primary metabolite of Antipyrine and functions as a biodistribution promoter. It has been shown to increase the distribution concentration ratio of Citicoline and Antipyrine in the brain.
- Enhances tissue-to-plasma concentration ratio of Citicoline in the brain and liver.
- Enhances tissue-to-plasma concentration ratio of thiopental sodium in the brain, liver, and heart.
- Improves blood-brain barrier (BBB) permeability of Antipyrine by increasing its Kp value in the brain.
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Medchemexpress LLC Methyl Blue | 28983-56-4 | MFCD00003507 | >=80% | 5 G
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Methyl blue belongs to the group of triaminotriphenylmethane dyes. It is extensively used as an antiseptic dye in polychrome staining methods and finds applications in histological and microbiological staining solutions. Methyl blue has also been utilized as a model to investigate the effect of various catalysts on the photodegradation of dyes.
- Antiseptic dye.
- Used in polychrome staining methods.
- Applicable in histological and microbiological staining solutions.
- Used as a model for studying photodegradation of dyes.
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Medchemexpress LLC Bix-01294 (trihydrochloride) | 1392399-03-9 | MFCD16618384 | 99.7% | 600.02 g/mol | C28H41Cl3N6O2 | 250 MG
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BIX-01294 trihydrochloride is a reversible, selective inhibitor of the histone methyltransferases G9a and GLP used for epigenetic research. It reduces H3K9 dimethylation and modulates gene expression and cell behavior in biochemical and cell-based assays; supplied as a light yellow solid with high reported purity.
- Reversible, selective inhibitor of G9a and GLP.
- Active in biochemical and cell assays at low micromolar concentrations.
- Reduces H3K9me2 levels and affects gene expression.
- High reported purity (>99%).
- Soluble in water and DMSO at stated concentrations.
- Powder stable at 4°C; solutions stable with frozen storage per guidance.
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